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Publications (see in Pubmed) (see in Google Scholar)
2023
The CDK12 inhibitor SR-4835 functions as a molecular glue that promotes cyclin K degradation in melanoma Houles T, Boucher J, Lavoie G, MacLeod G, Lin S, Angers S, Roux PP
Cell Death Discov. 9, 459 (2023)
CBFA2T3::GLIS2 Pediatric Acute Megakaryoblastic Leukemia is Sensitive to BCL-XL Inhibition by Navitoclax and DT2216
Gress V, Roussy M, Boulianne L, Bilodeau M, Cardin S, El-Hachem N, Lisi V, Khakipoor B, Rouette A, Farah A, Théret L, Aubert L, Fatima F, Audemard E, Thibault P, Bonneil E, Chagraoui J, Laramée L, Gendron P, Jouan L, Jammali S, Paré B, Simpson SM, Tran TH, Duval M, Teira P, Bittencourt H, Santiago R, Barabé F, Sauvageau G, Smith MA, Hébert J, Roux PP, Gruber TA, Lavallée VP, Wilhelm BT, Cellot S
Blood Adv. Sep 20, Online ahead of print (2023)
HER2Δ16 Engages ENPP1 to Promote an Immune-Cold Microenvironment in Breast Cancer
Attalla SS, Boucher J, Proud H, Taifour T, Zuo D, Sanguin-Gendreau V, Ling C, Johnson G, Li V, Luo RB, Kuasne H, Papavasiliou V, Walsh LA, Barok M, Joensuu H, Park M, Roux PP, Muller WJ
Cancer Immunol. Res. 11, 1184-1202 (2023)
In vivo CRISPR screens reveal Serpinb9 and Adam2 as regulators of immune therapy response in lung cancer
Dervovic D, Malik AA, Chen ELY, Narimatsu M, Adler N, Afiuni-Zadeh S, Krenbek D, Martinez S, Tsai R, Boucher J, Berman JM, Teng K, Ayyaz A, Lu Y, Mbamalu G, Loganathan SK, Lee J, Zhang L, Guidos C, Wrana J, Valipour A, Roux PP, Reimand J, Jackson HW, Schramek D.
Nature Commun. 14, 3150 (2023)
2022
CDK12 is hyperactivated and a synthetic-lethal target in BRAF-mutated melanoma
Houles T, Lavoie G, Nourreddine S, Cheung W, Vaillancourt-Jean E, Guerin CM, Bouttier M, Grondin B, Lin S, Saba-El-Leil MK, Angers S, Meloche S, Roux PP
Nature Commun. 13, 6457 (2022)
Proteomic analysis of the actin cortex in interphase and mitosis
Vadnjal N, Nourreddine S, Lavoie G, Serres M, Roux PP, Paluch EK
J. Cell Sci. 135, jcs259993 (2022)
Triglyceride-derived fatty acids reduce autophagy in a model of retinal angiomatous proliferation
Heckel E, Cagnone G, Agnihotri T, Cakir B, Das A, Kim JS, Kim N, Lavoie G, Situ A, Pundir S, Sun Y, Wunnemann F, Pierce KA, Dennis C, Mitchell GA, Chemtob S, Rezende FA, Andelfinger G, Clish CB, Roux PP, Sapieha P, Smith LE, Joyal JS
JCI Insight 7, e154174 (2022)
CEACAM1 is a novel culture-compatible surface marker of expanded long-term reconstituting hematopoietic stem cells
Ansari U, Tomellini E, Chagraoui J, Lehnertz B, Mayotte N, Bordeleau ME, Roux PP, Sauvageau G
Blood Adv. 6, 3626-3631 (2022)
2021
RIOK2 phosphorylation by RSK promotes synthesis of the human small ribosomal subunit
Cerezo EL, Houles T, Lie O, Sarthou MK, Audoynaud C, Lavoie G, Halladjian M, Cantaloube S, Froment C, Burlet-Schiltz O, Henry Y, Roux PP, Henras AK, Romeo Y
PLoS Genet. 17, e1009583 (2021)
Sustained ERK1/2 signaling is necessary for follicular rupture during ovulation in mice
Madogwe E, Schuermann Y, Siddappa D, Bordignon V, Roux PP, Duggavathi R
Reproduction 161, 183-193 (2021)
2020
Targeting copper metabolism to defeat KRAS-driven colorectal cancer
Aubert L, Nandagopal N, Roux PP
Mol. Cell. Oncol. 7, 1822123 (2020)
STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity
De Jamblinne CV, Decelle B, Dehghani M, Joseph M, Sriskandarajah N, Leguay K, Rambaud B, Lemieux S, Roux PP, Hipfner DR, Carreno S
J. Cell Biol. 219, e201911035 (2020)
Copper bioavailability is a KRAS-specific vulnerability in colorectal cancer
Aubert L, Nandagopal N, Steinhart Z, Lavoie G, Nourreddine S, Berman J, Saba-El-Leil MK, Papadopoli D, Lin S, Hart T, Macleod G, Topisirovic I, Gaboury L, Fahrni CJ, Schramek D, Meloche S, Angers S, Roux PP
Nature Commun. 11, 3701 (2020)
An ErbB2 splice variant lacking exon 16 drives lung carcinoma
Smith HW, Yang L, Ling C, Walsh A, Martinez VD, Boucher J, Zuo D, Sokol ES, Pavlick DC, Frampton GM, Chmielecki J, Jones LM, Roux PP, Lockwood WW, Muller WJ
Proc. Natl Acad. Sci. USA 1, 202007474 (2020)
SPIN90 associates with mDia1 and the Arp2/3 complex to regulate cortical actin organization
Cao L, Yonis A, Vaghela M, Barriga EH, Chugh P, Smith MB, Maufront J, Lavoie G, Meant A, Ferber E, Bovellan M, Alberts A, Bertin A, Mayor R, Paluch EK, Roux PP, Jegou A, Romet-Lemonne G, Charras G
Nature Cell Biol. 22, 803-814 (2020)
NF45 and NF90 regulate mitotic gene expression by competing with Staufen-mediated mRNA decay
Nourreddine S, Lavoie G, Paradis J, Ben El Kadhi K, Meant A, Aubert L, Grondin B, Gendron P, Chabot B, Bouvier M, Carreno S, Roux PP
Cell Reports 31, 107660 (2020)
Controversies around the function of LARP1
Berman AJ*, Thoreen CC*, Dedeic Z, Chettle J, Roux PP*, Blagden SP*
RNA Biol. 1, 1-11 (2020)
F-Actin interactome reveals Vimentin as a key regulator of Actin organization and cell mechanics in mitosis
Serres MP, Samwer M, Truong Quang BA, Petronczki M, Roux PP*, Paluch EK*
Dev. Cell 52, 210-222 (2020)
Loss of DP1 aggravates vascular remodeling in pulmonary arterial hypertension via mTORC1 signaling
He Y, Zuo C, Jia D, Bai P, Kong D, Chen D, Liu G, Li J, Wang Y, Chen G, Yan S, Xiao B, Zhang J, Piao L, Li Y, Deng Y, Li B, Roux PP, Andreasson KI, Breyer RM, Su Y, Wang J, Lyu A, Shen Y, Yu Y
Am. J. Respir. Crit. Care Med. 1, 1-15 (2020)
Proteomic analysis reveals a role for RSK in p120-catenin phosphorylation and melanoma cell-cell adhesion
Meant A, Gao B, Lavoie G, Nourreddine S, Jung F, Aubert L, Tcherkezian J, Gingras AC, Roux PP
Mol. Cell. Proteomics 19, 50-64 (2020)
2019
Regulation of protein kinase C delta Nuclear Import and Apoptosis by mTORC1
Layoun A, Goldberg AA, Baig A, Eng M, Attias O, Nelson K, Carella A, Amberber N, Fielhaber JA, Joung KB, Martin Schmeing T, Han Y, Downey J, Divangahi M, Roux PP, Kristof AS
Sci. Reports 9, 17620-33 (2019)
Human models of NUP98-KDM5A megakaryocytic leukemia in mice contribute to uncovering new biomarkers and therapeutic vulnerabilities
Cardin S, Bilodeau M, Roussy M, Aubert L, Milan T, Jouan L, Rouette A, Laramee L, Gendron P, Duchaine J, Decaluwe H, Spinella JF, Mourad S, Couture F, Sinnett D, Haddad E, Landry JR, Ma J, Humphries RK, Roux PP, Hebert J, Gruber TA, Wilhelm BT, Cellot S
Blood Advances 3, 3307-3321 (2019)
Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration
Plutoni C, Keil S, Zeledon C, Delsin LEA, Decelle B, Roux PP, Carreno S, Emery G
Nature Commun. 10, 3940 (2019)
Mubritinib targets the electron transport chain complex I and reveals the landscape of OXPHOS dependency in acute myeloid leukemia
Baccelli I, Gareau Y, Lehnertz B, Gingras S, Spinella JF, Corneau S, Mayotte N, Girard S, Frechette M, Blouin-Chagnon V, Leveille K, Boivin I, MacRae T, Krosl J, Thiollier C, Lavallee VP, Kanshin E, Bertomeu T, Coulombe-Huntington J, St-Denis C, Bordeleau ME, Boucher G, Roux PP, Lemieux S, Tyers M, Thibault P, Hebert J, Marinier A, Sauvageau G
Cancer Cell 36, 84-99 (2019)
Predisposing germline mutations in high hyperdiploid acute lymphoblastic leukemia in children
de Smith AJ, Lavoie G, Walsh KM, Aujla S, Evans E, Hansen HM, Smirnov I, Kang AY, Zenker M, Ceremsak JJ, Stieglitz E, Muskens IS, Roberts W, McKean-Cowdin R, Metayer C, Roux PP, Wiemels JL
Genes Chromosomes Cancer 58, 723-730 (2019)
ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation
Shin S, Buel GR, Nagiec MJ, Han MJ, Roux PP, Blenis J, Yoon SO
Proc. Natl Acad. Sci. USA 116, 2967-2976 (2019)
2018
The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression
Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JF
Cell Reports 23, 1476-1490 (2018)
Signaling pathways involved in the regulation of mRNA translation
Roux PP, Topisirovic I
Mol. Cell. Biol. 38, e00070-18 (2018)
RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma
Houles T, Gravel SP, Lavoie G, Shin S, Savall M, Meant A, Grondin B, Gaboury L, Yoon SO, St-Pierre J, Roux PP
Cancer Res. 78, 2191-2204 (2018)
CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3 adaptor protein
Ben Djoudi Ouadda A, He Y, Calabrese V, Ishii H, Chidiac R, Gratton JP, Roux PP, Lamarche-Vane N
Oncotarget 9, 11646-11664 (2018)
Defining the role of the RSK isoforms in cancer
Houles T, Roux PP
Semin. Cancer Biol. 48, 53-61 (2018)
2017
Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition
Yoon SO, Shin S, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP, Dephoure N, Blenis J
Mol. Cell 67, 1-16 (2017)
Actin cortex architecture regulates cell surface tension
Chugh P, Clark A, Smith M, Cassani D, Dierkes K, Ragab A, Roux PP, Charras G, Salbreux G, Paluch E
Nature Cell Biol. 19, 689-697 (2017)
EPCR expression marks UM171-expanded CD34+ cord blood stem cells
Fares I, Chagraoui J, Lehnertz B, MacRae T, Mayotte N, Tomellini E, Aubert L, Roux PP, Sauvageau G
Blood 129, 3344-3351 (2017)
A new inhibitor of the B-arrestin/AP-2 endocytic complex reveals interplay between GPCR internalization and signalling
Beautrait A, Paradis JS, Zimmerman B, Armando S, Khoury E, Audet M, Roux PP, Laporte SA, Bouvier M
Nature Commun. 8, 15054 (2017)
ERK1/2 phosphorylate Gab2 to promote a negative feedback loop that attenuates PI3K/Akt signaling
Zhang X, Lavoie G, Meant A, Aubert L, Cargnello M, Haman A, Hoang T, Roux PP
Mol. Cell. Biol. 37, e00357-16 (2017)
Proteomics screen identifies class I Rab11 family interacting proteins as key regulators of cytokinesis
Laflamme C, Galan JA, Ben El Kadhi K, Meant A, Zeledon C, Carreno S, Roux PP*, Emery*
Mol. Cell. Biol. 37, e00278-16 (2017)
2016
High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells
Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hebert J, Sauvageau G, Kwok BH, Roux PP, Hoang T.
J. Clin. Invest. 126, 4569-4584 (2016)
2015
Receptor sequestration in response to Beta-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels
of GPCR cell-surface expression
Paradis JS, Ly S, Blondel-Tepaza E, Galan JA, Beautrait A, Scott MGH, Enslen H, Marullo S, Roux PP*, Bouvier M*
Proc. Natl Acad. Sci. USA 112, E5160-8 (2015)
Regulation of global and specific mRNA translation by the mTOR signaling pathway
Nandagopal N, Roux PP
Translation 3, e983402 (2015)
The expanding role of mTOR in cancer cell growth and proliferation
Cargnello M, Tcherkezian J, Roux PP
Mutagenesis 30, 169-176 (2015)
Effect of the transient pharmacological inhibition of mapk3/1 pathway on ovulation in mice
Siddappa D, Beaulieu E, Gevry N, Roux PP, Bordignon V, Duggavathi R
PLoS One 10, e0119387 (2015)
Translational control by oncogenic signaling pathways
Gao B, Roux PP
Biochim. Biophys. Acta. 1849, 753-765 (2015)
2014
Phosphoproteomic Analysis Identifies the Tumor Suppressor PDCD4 as a RSK Substrate Negatively Regulated by 14-3-3
Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschkee GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP
Proc. Natl Acad. Sci. USA 111, E2918-27 (2014)
A Biosensor to monitor Dynamic Regulation and Function of Tumour Suppressor PTEN in Living Cells
Lima-Fernandes E, Misticone S, Boularan C, Paradis JS, Enslen H, Roux PP, Bouvier M, Baillie GS, Marullo S, Scott MGH
Nat. Comm. 5, 4431 (2014)
Cellular control of cortical actin nucleation
Bovellan M, Romeo Y, Biro M, Boden A, Chugh P, Yonis A, Vaghela M, Fritzsche M, Moulding D, Thorogate R, Jegou A, Thrasher AJ,Romet-Lemonne G, Roux PP*, Paluch EK*, Charras G*
Curr. Biol. 24, 1628-1635 (2014)
Mechanistic target of rapamycin (mTOR) signaling during ovulation in mice
Siddappa D, Kalaiselvanraja A, Bordignon V, Dupuis L, Gasperin BG, Roux PP, Duggavathi R.
Mol. Reprod. Dev. 81, 655-665 (2014)
Mutations in DOCK7 in Individuals with Epileptic Encephalopathy and Cortical Blindness
Perrault I, Hamdan FF, Rio M, Capo-Chichi JM, Boddaert N, Decarie JC, Maranda B, Nabbout R, Sylvain M, Lortie A, Roux PP, Rossignol E, Gerard X, Barcia G, Berquin P, Munnich A, Rouleau GA, Kaplan J, Rozetemail JM, Michaud JL
Am. J. Hum. Genet. 94, 1-7 (2014)
Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation
Tcherkezian J, Cargnello M, Romeo Y, Huttlin EL, Lavoie G, Gygi SP, Roux PP
Genes & Dev. 28, 357-371 (2014)
Casein kinase 1e
promotes cell proliferation by regulating mRNA translation
Shin S, Wolgamott L, Roux PP, Yoon SO
Cancer Res. 74, 201-211 (2014)
Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation
through the regulation of translation initiation factor 4E-binding protein 1
Shin S, Wolgamott L, Tcherkezian J, Vallabhapurapu S, Yu Y, Roux PP, Yoon SO.
Oncogene 33, 1690-1699 (2014)
2013
The coming of age of phosphoproteomics; From large data sets to inference of protein
functions
Roux PP, Thibault P
Mol. Cell. Proteomics. 12, 3453-3464 (2013)
Rapamycin resistance:
mTORC1 substrates hold some of the answers
Yoon SO, Roux PP
Curr. Biol. 23, R880-R883 (2013)
Gab2 Phosphorylation by
RSK Inhibits Shp2 Recruitment and Cell Motility
Zhang X, Lavoie G, Fort L, Huttlin EL,
Tcherkezian J, Galan JA, Gu H, Gygi SP, Carreno S, Roux PP.
Mol. Cell. Biol. 33, 1657-1670 (2013)
Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative
imaging
Biro M, Romeo Y, Kroschwald S, Bovellan M, Boden A, Tcherkezian J, Roux PP*, Charras G*, Paluch E*
Cytoskeleton 70, 741-754 (2013)
RSK promotes G2 DNA
damage checkpoint silencing and participates in melanoma chemoresistance
Ray-David H, Romeo Y, Lavoie G, Deleris P,
Tcherkezian J, Galan JA, Roux PP.
Oncogene 32, 4480-4489 (2013)
Insulin activates RSK to
trigger a new negative feedback loop that regulates insulin signaling
for glucose metabolism
Smadja-Lamere N, Shum M, Deleris P, Roux PP, Abe JI, Marette A.
J. Biol. Chem. 288, 31165-31176 (2013)
Cell cycle regulation of
Greatwall kinase localization facilitates mitotic progression
Wang P, Galan, JA, Bonneil E., Hickson GR, Roux PP,
Thibault P, Archambault V.
J. Cell. Biol. 202, 277-293 (2013)
Role of TBC1D7, a
subunit of the TSC1/TSC2 complex, in intellectual disability and
megalencephaly
Capo-Chichi JM, Tcherkezian J, Decarie JC,
Dobrzeniecka S, Patry L, Nadon MA, Mucha-Le Ny B, Shevell M, Cheikh BB,
Joober R, Samuels ME, Rouleau GA, Hamdan FF, Roux PP, Michaud JL.
J. Med. Genet. 50, 740-744 (2013)
RSK regulates activated
BRAF signalling to mTORC1 and promotes melanoma growth
Romeo Y, Moreau J, Zindy PJ, Saba-El-Leil
M, Lavoie G, Dandachi F, Baptissart M, Borden KLB, Meloche S, Roux PP.
Oncogene 32, 2917-26 (2013)
2012
Phosphorylation of the
Eukaryotic Translation Initiation Factor 4E-Transporter (4E-T) by c-Jun
N-Terminal Kinase Promotes Stress-Dependent P-Body Assembly
Cargnello M, Tcherkezian J, Dorn JF,
Huttlin EL, Maddox PS, Gygi SP, Roux PP.
Mol. Cell. Biol. 32, 4572-84 (2012)
Regulation of mRNA
Translation by Signaling Pathways
Roux PP, Topisirovic I.
Cold Spring Harb. Perspect. Biol. 4
(11) (2012)
RSK phosphorylates SOS1
creating 14-3-3-docking sites and negatively regulating MAPK activation
Saha M, Carriere A, Cheerathodi M, Zhang X,
Lavoie G, Rush J, Roux PP, Ballif BA.
Biochem. J. 447, 159-66 (2012)
F-box proteins elongate
translation during stress recovery
Meloche S, Roux PP.
Sci. Signal. 5, pe25 (2012)
PDF
Regulation of
Karyopherin-α1 and nuclear import by mTOR
Fielhaber JA, Tan J, Joung KB, Attias O,
Huegel S, Bader M, Roux PP, Kristof AS.
J. Biol. Chem. 287, 14325-35 (2012)
Regulation and function
of the RSK family of protein kinases
Romeo Y, Zhang X, Roux PP.
Biochem. J. 441, 553-69 (2012)
2011
The MHC I
immunopeptidome conveys to the cell surface an integrative view of
cellular regulation
Caron E, Vincent K, Fortier MH, Laverdure
JP, Bramoulle A, Hardy MP, Voisin G, Roux PP, Lemieux S, Thibault P,
Perreault C.
Mol. Syst. Biol. 7, 533 (2011)
Activation and function
of the MAPKs and their substrates, the MAPK-activated protein kinases
Cargnello, M., Roux, P.P.
Microbiol. Mol. Biol. Rev. 75, 50-83
(2011)
ERK1/2 phosphorylate
Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1)
Carriere, A., Romeo, Y., Acosta-Jaquez, H.A.,
Moreau, J., Bonneil, E., Thibault, P., Fingar, D.C., Roux, P.P.
J. Biol. Chem. 286, 567-77 (2011)
Paving the way for
targeting RSK in cancer
Romeo, Y.,
Roux, P.P.
Exp. Opin. Ther. Targets. 15, 5-9 (2011)
2010
A comprehensive map of
the mTOR signaling network
Caron E, Ghosh S, Matsuoka Y, Ashton-Beaucage
D, Therrien M, Lemieux S, Perreault C, Roux PP, Kitano H.
Mol. Syst. Biol. 6, 453 (2010)
The mammalian target of rapamycin (mTOR)
Med. Sci. 26, 1056-60 (2010)
mTORC2 can associate
with ribosomes to promote cotranslational phosphorylation and stability
of
Oh, W.J., Wu, C.C., Kim, S.J., Facchinetti,
V., Julien, L.A., Finlan, M., Roux, P.P., Su, B., Jacinto, E.
EMBO J. 29, 3939-51 (2010)
Transmembrane receptor
DCC associates with protein synthesis machinery and regulates
translation
Tcherkezian, J., Brittis, P.A., Thomas, F.,
Roux, P.P., Flanagan, J.G.
Cell 141, 632-44 (2010)
mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling
Mol. Cell. Biol. 30, 908-21 (2010)
Regulation of mTOR
complex 1 (mTORC1) by Raptor S863 and multi-site phosphorylation
Foster, K.G., Acosta-Jaquez, H.A., Romeo,
Y., Ekim, B., Soliman, G.A., Carriere, A., Roux, P.P., Ballif, B.A.,
Fingar, D.C.
J. Biol. Chem. 285, 80-94 (2010)
2008
Y-box binding protein-1
(YB-1) serine 102 is a downstream target of p90 ribosomal S6 kinase (RSK) in basal-like breast
cancer cells
Stratford, A.L., Fry, C.J., Desilets, C.,
Davies, A.H., Cho, Y.Y., Li, Y., Dong, Z., Berquin, I.M., Roux, P.P.,
Dunn, S.E.
Breast Cancer Res. 10, R99 (2008)
Choo, Y.A., Yoon, S., Kim, S.G., Roux,
P.P., Blenis, J.
Proc. Natl Acad. Sci. USA
105, 17414-9 (2008)
Oncogenic MAPK signaling stimulates mTORC1 activity by
promoting RSK-mediated Raptor phosphorylation
Carriere, A.,
Cargnello, M., Julien, L.-A., Gao, H., Bonneil, E., Thibault, P., Roux,
P.P.
Curr. Biol. 18, 1269-77
(2008)
See
comment in Nature
Reviews Cancer (2008) 8: 739 and in
Nature Signaling Gateway Update, Oct 2008
The RSK factors of activating the Ras/MAPK
signaling pathway
Carriere, A., Ray, H., Blenis,
J., Roux, P.P.
Frontiers in Bioscience
13, 4258-75 (2008)
2007
RSK4
Roux, P.P.
UCSD-Nature Molecule Pages (doi:10.1038/mp.a002102.01)(2007)
Rsk3
Roux, P.P.
UCSD-Nature Molecule Pages (doi:10.1038/mp.a002101.01)(2007)
Ras/ERK signaling promotes site-specific ribosomal
protein S6 phosphorylation via RSK and stimulates cap-dependent
translation
Roux, P.P., Shahbazian,
D., Vu, H., Holz, M.K., Cohen, M.S., Taunton, J., Sonenberg.
N.,
Blenis, J.
J.
Biol. Chem.
282, 14056-64 (2007)
Rsk1
Roux, P.P.
UCSD-Nature Molecule Pages (doi:10.1038/mp.a002099.01)(2007)
2006
Mind the
GAP: Wnt Steps onto the mTORC1
Train
Choo, A.Y.,
Roux, P.P., Blenis, J.
Cell 126, 8-10
(2006)
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its
phosphorylation and activity
Shahbazian,
D., Roux, P.P., Mieulet, V., Cohen, M.S., Raught, B., Taunton, J.,
Hershey, J.W.B., Blenis, J., Pende, M., Sonenberg, N.
EMBO J. 25, 2781-91
(2006)
2005
The proapoptotic
tumor suppressor DAP kinase is a target of RSK-mediated survival
signaling
Anjum, R.,
Roux, P.P., Ballif, B.A., Gygi, S.P., Blenis, J.
Curr. Biol.
15, 1762-67 (2005)
Quantitative and temporal phosphorylation profiling of the ERK-RSK
signaling cassette and its target the tuberous sclerosis complex (TSC)
tumor suppressor proteins
Ballif,
B.A.,*
Roux, P.P.,*
Gerber, S.A., MacKeigan, J.P., Blenis, J., Gygi, S.P. * Co-First
authors
Proc. Natl Acad. Sci. USA
102, 667-72 (2005)
2004
Tumor promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor
suppressor complex via RSK
Roux, P.P.,
Ballif, B.A., Anjum, R., Gygi, S.P., Blenis, J.
Proc. Natl Acad. Sci. USA
101, 13489-94 (2004)
The ERK and p38 MAPK-activated protein kinases (MKs):
a family of protein kinases with diverse biological functions
Roux,
P.P., Blenis, J.
Microbiol. Mol. Biol. Rev. 68, 320-44
(2004)
Protein kinase A activation promotes
plasma membrane insertion of DCC from an intracellular pool: a novel
mechanism regulating commissural axon extension
Bouchard,
J.-F., Moore, S.W., Tritsch, N.X., Roux, P.P., Shekarabi, M., Barker,
P.A., and Kennedy, T.E.
J.
Neurosci. 24, 3040-50 (2004)
2003
Phosphorylation of p90 ribosomal
S6 kinase (RSK) regulates ERK docking and RSK activity
Roux,
P.P., Richards, S.A., Blenis, J.
Mol. Cell. Biol. 23:4796-804 (2003)
Tuberous sclerosis complex gene products,
Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating
protein complex toward Rheb
Tee, A.R.,
Manning, B.D., Roux, P.P., Cantley, L.C., Blenis, J.
Curr. Biol. 13, 1259-68
(2003)
2002
K252a and CEP1347 are neuroprotective compounds that inhibit
mixed-lineage kinase-3 and induce activation of Akt and ERK
Roux,
P.P., Dorval, G, Boudreau, M., Angers-Loustau, A., Morris, S.J., Makkerh,
J., Barker, P.A.
J. Biol. Chem.
277, 49473-80 (2002)
Neurotrophin signaling through the p75
neurotrophin receptor
Roux,
P.P., Barker, P.A.
Prog. Neurobiol.
67, 203-33 (2002)
2001
The p75 neurotrophin receptor (p75NTR) activates Akt (Protein kinase B) through
a Phosphatidylinositol 3-kinase-dependent pathway
Roux,
P.P.,
Bhakar, A.L., Kennedy, T.E., Barker, P.A.
J. Biol. Chem. 276, 23097-104
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2000
Activation of transcription factors NF-kappaB and NF-IL-6 by
human immunodeficiency virus type 1 protein R (Vpr) induces
interleukin-8 expression
Roux,
P.,
Alfieri, C., Hrimech, M., Cohen, E.A., Tanner, J.E.
J. Virol. 74, 4658-65 (2000)
NRAGE, a novel MAGE
protein, interacts with the p75 neurotrophin receptor and facilitates
nerve growth factor dependent apoptosis
Salehi,
A.H., Roux, P.P., Kubu, C.J., Zeindler, C., Bhakar, A.,
Tannis, L.-L., Verdi, J.M., Barker, P.A.
Neuron 27, 279-88
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1999
p75 neurotrophin receptor expression is induced in apoptotic neurons after
seizure
Roux,
P.P.,
Colicos, M.A., Barker, P.A., Kennedy, T.E.
J. Neurosci. 19, 6887-96 (1999)
The p75 neurotrophin receptor alters TNF-mediated NF-kappaB activity in
cell types which show no direct p75NTR-mediated NF-kappaB activation
Bhakar, A.L.,
Roux, P.P., Lachance, C., Kryl, D., Zeindler, C., Barker, P.A.
J. Biol. Chem.
274, 21443-9 (1999)
1998
Increased apoptosis, changes in
intracellular Ca++ and functional alterations in lymphocytes and
macrophages after in vitro exposure to static magnetic fields
Flipo, D.,
Fournier, M., Benquet, C., Roux, P., Le Boulaire, C., Pinsky, C.,
LaBella, F.S., Krzystyniak, K.
J. Toxicol. Environm. Health 54, 63-76
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