Roux Lab                             Laboratory of Cell Signalling and Proteomics

Publications (see in Pubmed) (see in Google Scholar)




ERK2 regulates epithelial-to-mesenchymal plasticity through DOCK10-dependent Rac1/FoxO1 activation

Shin S, Buel GR, Nagiec MJ, Han MJ, Roux PP, Blenis J, Yoon SO

Proc. Natl Acad. Sci. USA. Epub ahead of print (2019)




The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression

Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JF

Cell Reports 23, 1476-1490 (2018)


Signaling pathways involved in the regulation of mRNA translation

Roux PP, Topisirovic I

Mol. Cell. Biol. 38, e00070-18 (2018)


RSK Regulates PFK-2 Activity to Promote Metabolic Rewiring in Melanoma

Houles T, Gravel SP, Lavoie G, Shin S, Savall M, Meant A, Grondin B, Gaboury L, Yoon SO, St-Pierre J, Roux PP

Cancer Res. 78, 2191-2204 (2018)


CdGAP/ARHGAP31 is regulated by RSK phosphorylation and binding to 14-3-3 adaptor protein

Ben Djoudi Ouadda A, He Y, Calabrese V, Ishii H, Chidiac R, Gratton JP, Roux PP, Lamarche-Vane N

Oncotarget 9, 11646-11664 (2018)


Defining the role of the RSK isoforms in cancer

Houles T, Roux PP

Semin. Cancer Biol. 48, 53-61 (2018)




Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition

Yoon SO, Shin S, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP, Dephoure N, Blenis J

Mol. Cell 67, 1-16 (2017)


Actin cortex architecture regulates cell surface tension

Chugh P, Clark A, Smith M, Cassani D, Dierkes K, Ragab A, Roux PP, Charras G, Salbreux G, Paluch E

Nature Cell. Biol. 19, 689-697 (2017)


EPCR expression marks UM171-expanded CD34+ cord blood stem cells

Fares I, Chagraoui J, Lehnertz B, MacRae T, Mayotte N, Tomellini E, Aubert L, Roux PP, Sauvageau G

Blood. 129, 3344-3351 (2017)


A new inhibitor of the B-arrestin/AP-2 endocytic complex reveals interplay between GPCR internalization and signalling

Beautrait A, Paradis JS, Zimmerman B, Armando S, Khoury E, Audet M, Roux PP, Laporte SA, Bouvier M

Nature Commun. 8, 15054 (2017)


ERK1/2 phosphorylate Gab2 to promote a negative feedback loop that attenuates PI3K/Akt signaling

Zhang X, Lavoie G, Meant A, Aubert L, Cargnello M, Haman A, Hoang T, Roux PP

Mol. Cell. Biol. 37, e00357-16 (2017)


Proteomics screen identifies class I Rab11 family interacting proteins as key regulators of cytokinesis

Laflamme C, Galan JA, Ben El Kadhi K, Meant A, Zeledon C, Carreno S, Roux PP*, Emery*

Mol. Cell. Biol. 37, e00278-16 (2017)




High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells

Gerby B, Veiga DF, Krosl J, Nourreddine S, Ouellette J, Haman A, Lavoie G, Fares I, Tremblay M, Litalien V, Ottoni E, Kosic M, Geoffrion D, Ryan J, Maddox PS, Chagraoui J, Marinier A, Hebert J, Sauvageau G, Kwok BH, Roux PP, Hoang T.

J. Clin. Invest. 126, 4569-4584 (2016)




Receptor sequestration in response to Beta-arrestin-2 phosphorylation by ERK1/2 governs steady-state levels of GPCR cell-surface expression

Paradis JS, Ly S, Blondel-Tepaza E, Galan JA, Beautrait A, Scott MGH, Enslen H, Marullo S, Roux PP*, Bouvier M*

Proc. Natl Acad. Sci. USA. 112, E5160-8 (2015)


Regulation of global and specific mRNA translation by the mTOR signaling pathway

Nandagopal N, Roux PP

Translation 3, e983402 (2015)


The expanding role of mTOR in cancer cell growth and proliferation

Cargnello M, Tcherkezian J, Roux PP

Mutagenesis 30, 169-176 (2015)


Effect of the transient pharmacological inhibition of mapk3/1 pathway on ovulation in mice

Siddappa D, Beaulieu E, Gevry N, Roux PP, Bordignon V, Duggavathi R

PLoS One 10, e0119387 (2015)


Translational control by oncogenic signaling pathways

Gao B, Roux PP

Biochim. Biophys. Acta. 1849, 753-765 (2015)




Phosphoproteomic Analysis Identifies the Tumor Suppressor PDCD4 as a RSK Substrate Negatively Regulated by 14-3-3

Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschkee GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP

Proc. Natl Acad. Sci. USA. 111, E2918-27 (2014)


A Biosensor to monitor Dynamic Regulation and Function of Tumour Suppressor PTEN in Living Cells

Lima-Fernandes E, Misticone S, Boularan C, Paradis JS, Enslen H, Roux PP, Bouvier M, Baillie GS, Marullo S, Scott MGH

Nat. Commun. 5, 4431 (2014)


Cellular control of cortical actin nucleation

Bovellan M, Romeo Y, Biro M, Boden A, Chugh P, Yonis A, Vaghela M, Fritzsche M, Moulding D, Thorogate R, Jegou A, Thrasher AJ,Romet-Lemonne G, Roux PP*, Paluch EK*, Charras G*

Curr. Biol. 24, 1628-1635 (2014)


Mechanistic target of rapamycin (mTOR) signaling during ovulation in mice

Siddappa D, Kalaiselvanraja A, Bordignon V, Dupuis L, Gasperin BG, Roux PP, Duggavathi R.

Mol Reprod Dev. 81, 655-665 (2014)


Mutations in DOCK7 in Individuals with Epileptic Encephalopathy and Cortical Blindness

Perrault I, Hamdan FF, Rio M, Capo-Chichi JM, Boddaert N, Decarie JC, Maranda B, Nabbout R, Sylvain M, Lortie A, Roux PP, Rossignol E, Gerard X, Barcia G, Berquin P, Munnich A, Rouleau GA, Kaplan J, Rozetemail JM, Michaud JL

Am J Hum Genet. 94, 1-7 (2014)


Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation

Tcherkezian J, Cargnello M, Romeo Y, Huttlin EL, Lavoie G, Gygi SP, Roux PP

Genes & Dev. 28, 357-371 (2014)


Casein kinase 1e promotes cell proliferation by regulating mRNA translation

Shin S, Wolgamott L, Roux PP, Yoon SO

Cancer Res. 74, 201-211 (2014)


Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1

Shin S, Wolgamott L, Tcherkezian J, Vallabhapurapu S, Yu Y, Roux PP, Yoon SO.

Oncogene. 33, 1690-1699 (2014)




The coming of age of phosphoproteomics; From large data sets to inference of protein functions

Roux PP, Thibault P

Mol. Cell. Proteomics. 12, 3453-3464 (2013)


Rapamycin resistance: mTORC1 substrates hold some of the answers

Yoon SO, Roux PP

Curr. Biol. 23, R880-R883 (2013)


Gab2 Phosphorylation by RSK Inhibits Shp2 Recruitment and Cell Motility

Zhang X, Lavoie G, Fort L, Huttlin EL, Tcherkezian J, Galan JA, Gu H, Gygi SP, Carreno S, Roux PP.

Mol. Cell. Biol. 33, 1657-1670 (2013)

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging

Biro M, Romeo Y, Kroschwald S, Bovellan M, Boden A, Tcherkezian J, Roux PP*, Charras G*, Paluch E*

Cytoskeleton. 70, 741-754 (2013)


RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance

Ray-David H, Romeo Y, Lavoie G, Deleris P, Tcherkezian J, Galan JA, Roux PP.

Oncogene. 32, 4480-4489 (2013)


Insulin activates RSK to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism

Smadja-Lamere N, Shum M, Deleris P, Roux PP, Abe JI, Marette A.

J. Biol. Chem. 288, 31165-31176 (2013)


Cell cycle regulation of Greatwall kinase localization facilitates mitotic progression

Wang P, Galan, JA, Bonneil E., Hickson GR, Roux PP, Thibault P, Archambault V.

J. Cell. Biol. 202, 277-293 (2013)


Role of TBC1D7, a subunit of the TSC1/TSC2 complex, in intellectual disability and megalencephaly

Capo-Chichi JM, Tcherkezian J, Decarie JC, Dobrzeniecka S, Patry L, Nadon MA, Mucha-Le Ny B, Shevell M, Cheikh BB, Joober R, Samuels ME, Rouleau GA, Hamdan FF, Roux PP, Michaud JL.

J. Med. Genet. 50, 740-744 (2013)


RSK regulates activated BRAF signalling to mTORC1 and promotes melanoma growth

Romeo Y, Moreau J, Zindy PJ, Saba-El-Leil M, Lavoie G, Dandachi F, Baptissart M, Borden KLB, Meloche S, Roux PP.

Oncogene. 32, 2917-26 (2013)




Phosphorylation of the Eukaryotic Translation Initiation Factor 4E-Transporter (4E-T) by c-Jun N-Terminal Kinase Promotes Stress-Dependent P-Body Assembly

Cargnello M, Tcherkezian J, Dorn JF, Huttlin EL, Maddox PS, Gygi SP, Roux PP.

Mol. Cell. Biol. 32, 4572-84 (2012)


Regulation of mRNA Translation by Signaling Pathways

Roux PP, Topisirovic I.

Cold Spring Harb. Perspect. Biol. 4 (11) (2012)


RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation

Saha M, Carriere A, Cheerathodi M, Zhang X, Lavoie G, Rush J, Roux PP, Ballif BA.

Biochem. J. 447, 159-66 (2012)


F-box proteins elongate translation during stress recovery

Meloche S, Roux PP.

Sci. Signal. 5, pe25 (2012) PDF


Regulation of Karyopherin-α1 and nuclear import by mTOR

Fielhaber JA, Tan J, Joung KB, Attias O, Huegel S, Bader M, Roux PP, Kristof AS.

J. Biol. Chem. 287, 14325-35 (2012)


Regulation and function of the RSK family of protein kinases

Romeo Y, Zhang X, Roux PP.

Biochem. J. 441, 553-69 (2012)




The MHC I immunopeptidome conveys to the cell surface an integrative view of cellular regulation

Caron E, Vincent K, Fortier MH, Laverdure JP, Bramoulle A, Hardy MP, Voisin G, Roux PP, Lemieux S, Thibault P, Perreault C.

Mol. Syst. Biol. 7, 533 (2011)


Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases

Cargnello, M., Roux, P.P.

Microbiol. Mol. Biol. Rev. 75, 50-83 (2011)

ERK1/2 phosphorylate Raptor to promote Ras-dependent activation of mTOR complex 1 (mTORC1) Carriere, A., Romeo, Y., Acosta-Jaquez, H.A., Moreau, J., Bonneil, E., Thibault, P., Fingar, D.C., Roux, P.P.

J. Biol. Chem. 286, 567-77 (2011)

Paving the way for targeting RSK in cancer

Romeo, Y., Roux, P.P.

Exp. Opin. Ther. Targets. 15, 5-9 (2011)




A comprehensive map of the mTOR signaling network

Caron E, Ghosh S, Matsuoka Y, Ashton-Beaucage D, Therrien M, Lemieux S, Perreault C, Roux PP, Kitano H.

Mol. Syst. Biol. 6, 453 (2010)

The mammalian target of rapamycin (mTOR)
Julien, L.A., Roux, P.P.

Med. Sci. 26, 1056-60 (2010)


mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of
nascent Akt polypeptide

Oh, W.J., Wu, C.C., Kim, S.J., Facchinetti, V., Julien, L.A., Finlan, M., Roux, P.P., Su, B., Jacinto, E.

EMBO J. 29, 3939-51 (2010)


Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation

Tcherkezian, J., Brittis, P.A., Thomas, F., Roux, P.P., Flanagan, J.G.

Cell 141, 632-44 (2010)


mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling
Julien, L.A., Carriere, A., Moreau, J., Roux, P.P.

Mol. Cell. Biol. 30, 908-21 (2010)


Regulation of mTOR complex 1 (mTORC1) by Raptor S863 and multi-site phosphorylation

Foster, K.G., Acosta-Jaquez, H.A., Romeo, Y., Ekim, B., Soliman, G.A., Carriere, A., Roux, P.P., Ballif, B.A., Fingar, D.C.

J. Biol. Chem. 285, 80-94 (2010)




Y-box binding protein-1 (YB-1) serine 102 is a downstream target of p90 ribosomal S6 kinase (RSK) in basal-like breast cancer cells

Stratford, A.L., Fry, C.J., Desilets, C., Davies, A.H., Cho, Y.Y., Li, Y., Dong, Z., Berquin, I.M., Roux, P.P., Dunn, S.E.

Breast Cancer Res. 10, R99 (2008)

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

Choo, Y.A., Yoon, S., Kim, S.G., Roux, P.P., Blenis, J.

Proc. Natl Acad. Sci. USA 105, 17414-9 (2008)


Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated Raptor phosphorylation

Carriere, A., Cargnello, M., Julien, L.-A., Gao, H., Bonneil, E., Thibault, P., Roux, P.P.

Curr. Biol. 18, 1269-77 (2008)

See comment in Nature Reviews Cancer (2008) 8: 739 and in Nature Signaling Gateway Update, Oct 2008


The RSK factors of activating the Ras/MAPK signaling pathway

Carriere, A., Ray, H., Blenis, J., Roux, P.P.

Frontiers in Bioscience 13, 4258-75 (2008)





Roux, P.P.

UCSD-Nature Molecule Pages (doi:10.1038/mp.a002102.01)(2007)



Roux, P.P.

UCSD-Nature Molecule Pages (doi:10.1038/mp.a002101.01)(2007)


Ras/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

Roux, P.P., Shahbazian, D., Vu, H., Holz, M.K., Cohen, M.S., Taunton, J., Sonenberg. N., Blenis, J.

J. Biol. Chem. 282, 14056-64 (2007)



Roux, P.P.

UCSD-Nature Molecule Pages (doi:10.1038/mp.a002099.01)(2007)




Mind the GAP: Wnt Steps onto the mTORC1 Train

Choo, A.Y., Roux, P.P., Blenis, J.

Cell 126, 8-10 (2006)


The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

Shahbazian, D., Roux, P.P., Mieulet, V., Cohen, M.S., Raught, B., Taunton, J., Hershey, J.W.B., Blenis, J., Pende, M., Sonenberg, N.

EMBO J. 25, 2781-91 (2006)




The proapoptotic tumor suppressor DAP kinase is a target of RSK-mediated survival signaling

Anjum, R., Roux, P.P., Ballif, B.A., Gygi, S.P., Blenis, J.

Curr. Biol. 15, 1762-67 (2005)


Quantitative and temporal phosphorylation profiling of the ERK-RSK signaling cassette and its target the tuberous sclerosis complex (TSC) tumor suppressor proteins

Ballif, B.A.,* Roux, P.P.,* Gerber, S.A., MacKeigan, J.P., Blenis, J., Gygi, S.P. * Co-First authors

Proc. Natl Acad. Sci. USA 102, 667-72 (2005)




Tumor promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via RSK

Roux, P.P., Ballif, B.A., Anjum, R., Gygi, S.P., Blenis, J.

Proc. Natl Acad. Sci. USA 101, 13489-94 (2004)


The ERK and p38 MAPK-activated protein kinases (MKs): a family of protein kinases with diverse biological functions

Roux, P.P., Blenis, J.

Microbiol. Mol. Biol. Rev. 68, 320-44 (2004)


Protein kinase A activation promotes plasma membrane insertion of DCC from an intracellular pool: a novel mechanism regulating commissural axon extension

Bouchard, J.-F., Moore, S.W., Tritsch, N.X., Roux, P.P., Shekarabi, M., Barker, P.A., and Kennedy, T.E.

J. Neurosci. 24, 3040-50 (2004)




Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates ERK docking and RSK activity

Roux, P.P., Richards, S.A., Blenis, J.

Mol. Cell. Biol. 23:4796-804 (2003)


Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

Tee, A.R., Manning, B.D., Roux, P.P., Cantley, L.C., Blenis, J.

Curr. Biol. 13, 1259-68 (2003)




K252a and CEP1347 are neuroprotective compounds that inhibit mixed-lineage kinase-3 and induce activation of Akt and ERK

Roux, P.P., Dorval, G, Boudreau, M., Angers-Loustau, A., Morris, S.J., Makkerh, J., Barker, P.A.

J. Biol. Chem. 277, 49473-80 (2002)


Neurotrophin signaling through the p75 neurotrophin receptor

Roux, P.P., Barker, P.A.

Prog. Neurobiol. 67, 203-33 (2002)




The p75 neurotrophin receptor (p75NTR) activates Akt (Protein kinase B) through a Phosphatidylinositol 3-kinase-dependent pathway

Roux, P.P., Bhakar, A.L., Kennedy, T.E., Barker, P.A.

J. Biol. Chem. 276, 23097-104 (2001)




Activation of transcription factors NF-kappaB and NF-IL-6 by human immunodeficiency virus type 1 protein R (Vpr) induces interleukin-8 expression

Roux, P., Alfieri, C., Hrimech, M., Cohen, E.A., Tanner, J.E.

J. Virol. 74, 4658-65 (2000)


NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor dependent apoptosis

Salehi, A.H., Roux, P.P., Kubu, C.J., Zeindler, C., Bhakar, A., Tannis, L.-L., Verdi, J.M., Barker, P.A.

Neuron 27, 279-88 (2000)




p75 neurotrophin receptor expression is induced in apoptotic neurons after seizure

Roux, P.P., Colicos, M.A., Barker, P.A., Kennedy, T.E.

J. Neurosci. 19, 6887-96 (1999)


The p75 neurotrophin receptor alters TNF-mediated NF-kappaB activity in cell types which show no direct p75NTR-mediated NF-kappaB activation

Bhakar, A.L., Roux, P.P., Lachance, C., Kryl, D., Zeindler, C., Barker, P.A.

J. Biol. Chem. 274, 21443-9 (1999)




Increased apoptosis, changes in intracellular Ca++ and functional alterations in lymphocytes and macrophages after in vitro exposure to static magnetic fields

Flipo, D., Fournier, M., Benquet, C., Roux, P., Le Boulaire, C., Pinsky, C., LaBella, F.S., Krzystyniak, K.

J. Toxicol. Environm. Health 54, 63-76 (1998)